When medications don’t mix: drug-drug interactions in mental health treatment
Drug-drug interactions can pose serious risks to your mental and physical health.
A fifth of the US population – more than a million people – reported experiencing mental health issues over the past year. Meeting the mental health needs of your employees is tougher than ever as demand for these services is soaring and the number of mental health providers can’t meet the need. It’s critical to assess all of the options available with an eye towards accessibility, efficacy, and safety, while understanding that many will end up on the path of prescription medications, OTC medications or a mix of both.
One of the trickiest issues in psychiatry is what’s known as a “drug-drug interaction,” or DDI. A DDI happens when an employee takes multiple medications and the pairing alters the effects of the drug(s) on the body. This could potentially include toxic side effects, the development of new symptoms, or one or more of the drugs not working properly. With nearly 50% of people taking prescription drugs, and half of those on three or more medications at once, DDIs have become very common.
Most common interactions
What DDIs do we need to worry about in the world of mental health? It’s not an easy question to answer. Psychiatric drugs work on the brain – our most complex organ – but they can still affect other parts of the body. Because of that, prescribing clinicians acknowledge that “identifying DDIs with psychiatric medications is perhaps more challenging than in any other area of medicine.” DDIs can occur between prescription medications, over-the-counter drugs or even supplements. While it would be impossible to list the thousands of DDIs that can occur with mental health medications, let’s look at some examples.
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During the COVID-19 public health emergency, Sleepio and Daylight are being made available as treatments for insomnia disorder and generalized anxiety disorder (GAD), respectively, without a prescription. Sleepio and Daylight have not been cleared by the U.S. Food and Drug Administration (FDA) for the treatment of insomnia disorder and GAD, respectively.
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